Why lopinavir and hydroxychloroquine do not work on COVID-19

Lopinavir is a drug against HIV, hydroxychloroquine is used to treat malaria and rheumatism. Until recently, both drugs were regarded as potential agents in the fight against the coronavirus SARS-CoV-2. Researchers have now discovered that the concentration of the two drugs in the lungs of Covid-19 patients is not sufficient to fight the virus.